Sertraline Wikipedia
CYP2C19 and CYP2B6 are thought to be the key cytochrome P450 enzymes involved in the metabolism of sertraline. Unchanged sertraline was not detectable in urine, whereas 12 to 14% of unchanged sertraline was present in feces. In a small study of two males, sertraline was excreted to similar degrees in urine and feces (40 to 45% each within 9 days). The elimination half-life of sertraline is on average 26 hours, with a range of 13 to 45 hours. In addition to the cytochrome P450 system,...
Read More